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The SELECT cardiovascular outcomes trial (N=17,604) demonstrated that semaglutide 2.4 mg reduced major adverse cardiovascular events (MACE) by 20% over a mean follow-up of 39.8 months, a finding that strengthens re-authorization arguments for patients with established cardiovascular disease [5]

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A prior episode of acute pancreatitis on semaglutide should prompt a careful risk-benefit discussion before switching to tirzepatide rather than a straightforward transition

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