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Particularly concerning, it appears that some studies were either canceled or stopped without conclusions

Co-enzyme B12 also interacts with the enzyme methionine synthase (5-methyltetrahydrofolate-homocysteine methyltransferase), required for the conversion of homocysteine to methionine, which is essential for folic acid metabolism and the formation of thymine, which is a component of DNA

Raised iron levels can also be genetic in origin

Split dosing (dividing the daily amount into two injections, morning and evening) maintains more consistent tissue levels throughout the day