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coli and together with the DsbC/D thiol disulfide isomerase system forms the oxidative folding machinery (Collet and Bardwell, 2002

Several studies support its efficacy in various organ systems affected during sepsis

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The process of detoxification proceeds in three parts or phases, Phase I, Phase II, and Phase lll

The aforementioned pathological changes during the ischemic and reperfusion phasesincluding calcium overload, mitochondrial dysfunction, oxidative stress surge, inflammatory cascade activation, cell death network formation, and microcirculatory dysfunctionare systematically visualized in the schematic diagram, which clearly depicts e sequential progression and interconnections of these mechanisms (Figs