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Gallbladder problems (e.g., pain in your belly, right shoulder area, or between the shoulder blades, pale-colored stools, dark urine, yellow skin or eyes, fever or chills)
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Several segments in the ECD of GCGR, the stalk between ECD and transmembrane helix 1 (TM1) of GLP-1R (residues 130135), extracellular loop 1 (ECL1) of GIPR (residues 202207), and intracellular loop 3 (ICL3) of GLP-1R and GIPR (residues 338343 and 330333, respectively) were poorly resolved and not modeled in the structures
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Subsequently, the expression levels of GLP-1R and inflammation-related factors in the articular cartilage tissues were detected by RT-qPCR and immunohistochemistry
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