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Many plans impose step therapy requirements, forcing patients to fail cheaper agents first before approving expensive GLP-1s

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Compared with the control, GLP-1 levels were higher between t = 60 min and t = 120 min after Met (60 min) and between t = 60 min and t = 90 min after Met (30 min)

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These substitutions preserve receptor affinity while enabling pharmaceutical-grade solubility

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