GLP-1 medications mimic a natural gut hormone that lowers blood sugar, slows digestion and helps people feel full and lose weight, but where semaglutide drugs like Wegovy and Saxenda only mimic GLP-1 receptors, tirzepatide medications, better known as Zepbound for weight loss and Mounjaro for treatment of Type 2 diabetes, mimic two receptors
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2.5 Statistical analysis We pooled hazard ratios (HRs) and corresponding 95% confidence intervals (CIs) using the DerSimonian and Laird random-effects model, which accounts for between study heterogeneity
Treatment discontinuation due to side effects occurred in up to 6.7% of those receiving Zepbound (primary in the first few months due to stomach side effects) and 3.4 % for the placebo group
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