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Unlike CJC-1295, it lacks the modifications that provide DPP-IV resistance
When compared with degludec in the SURPASS 3 trial, GI side effects were more common in the tirzepatide group, but hypoglycaemia was more common in people treated with degludec (12% versus 7%)
While both are manufactured by Eli Lilly and both activate the GLP-1 and GIP receptors, retatrutide is a triple agonist that also activates the glucagon receptor
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