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Three main paths exist: Weeks 37-48 Summary: Completion and Planning Weight loss: 3-7 pounds this period (49-53 pounds total, ~24% of starting weight average) Weekly loss rate: 0.25-0.6 pounds weekly (minimal but still progressing) Final results: 24.2% average total body weight loss by week 48 Discontinuation rate: 1-2% during this period Overall completion rate: 74% of people who started week 1 completed week 48 Psychological state: Proud of achievement, planning next steps What Actually Determines Your Timeline Results Individual timelines vary from the averages presented

Individual results vary based on starting weight, adherence, diet, exercise, and metabolic factors

Lee, S., Boesch, C., Kuk, J

Ongoing awareness of active and upcoming clinical trials enables clinicians to inform patients about potential access to new therapies and treatment strategies

While the upfront expense of semaglutide GLP-1 may appear significant, the long-term value it provides proves well worth the cost for many patients