is zepbound tirzepatide or semaglutide Tops for Weight Loss in Head-to-Head Trial, Eli Lilly Says Zepbound vs Semaglutide: Which Works

These include: Nausea (very common), typically most pronounced in the first few weeks Vomiting and diarrhoea (common), which can contribute to dehydration Constipation (common), which may require dietary adjustments Abdominal pain and bloating (common), related to delayed gastric emptying Reduced appetite (very common), which whilst therapeutically beneficial for weight loss, may lead to inadequate nutrition if extreme These effects usually diminish over time as tolerance develops

In other words, after a year, participants had regained two-thirds of the weight they had lost previously

Of particular note, as someone at the conference asked about the cardiac side effects reported in both trials, the presenters were quick to note the cardiac events were sinus tachycardia, ventricular extrasystoles noted on EKG(aka PVCs, something common and usually of no concern) and a couple patients reporting palpitations

MOTS-C generally has no significant drug interactions

January 15, 2026: California Man Sues Novo Nordisk After Taking Ozempic and Losing His Vision A man from California has brought a lawsuit against Novo Nordisk, the company that manufactures Ozempic