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Cheapest oral option: Rybelsus 14 mg tablets at $250 to $300 per month

Furthermore, several of these therapies have only a modest glucose-lowering effect in people with reduced glomerular filtration [14]

Baek MC et al

Vitamin B12 deficiency has obvious consequences

Compound Receptors Peak trial weight loss Lean mass as share of loss Semaglutide (Ozempic/Wegovy) GLP-1 ~14.9% (STEP-1, 68 wk) ~39% Tirzepatide (Mounjaro/Zepbound) GLP-1 + GIP ~20.9% (SURMOUNT-1, 72 wk) ~25-40% Retatrutide GLP-1 + GIP + GCGR ~24.2% (Phase 2, 48 wk) Comparable class range Best for understanding the takeaway: the percentage of loss that is lean mass is roughly constant across the class