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The proposed peptide mapping method using UPLC-HRMS was useful for determining active ingredient sameness between generic synthetic peptides and previously approved peptide drug products of rDNA origin

Conversely, treatment of rats with the GIPR antagonist, rat GIP (330)NH2, does not modify food intake but significantly increases plasma TG and LPL compared with controls (Szalowska et al., 2011)

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An earlier 12-week trial in 300 obese adults produced a genuine positive signal the 1 mg daily dosing arm showed a statistically significant 2.8 kg mean weight loss versus 0.8 kg in the placebo group and that result is what justified moving into the larger Phase IIb trial