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Along with the duodenum, GLP-1 agonists arise naturally in the brain, lungs and musculoskeletal system, as well as the pancreas and the kidney

To further explain the increased plasma concentrations in cirrhotic mice, the model predicted a 28-fold increase of UGT for OH-MDZ-G, a 3.9-fold increase for C6G, and no changes for M3G (Figure 6A