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It also increases insulin resistance and hepatic glucose production, frequently leading to impaired glucose tolerance or diabetes

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The foregoing result suggests that acylation, while beneficial for enhancing serum stability by increasing albumin binding, may impair BBB permeability

Abstract Glucagon-like peptide 1 (GLP1) receptor (GLP1R) agonists and tirzepatide, a dual GLP1R and glucose-dependent insulinotropic polypeptide receptor agonist, have become fundamental in managing type 2 diabetes mellitus (T2DM) and obesity due to their potent glycaemia-lowering and weight-lowering effects as well as their cardiovascular and renal benefits