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The Relationships between Gut Microbiota and Diabetes Mellitus, and Treatments for Diabetes Mellitus

A 2023 study found that, for individuals who successfully reduced their weight (the study cohort reduced their BMI by an average of 23%), there was a substantial reduction in group health insurance payments: Where group insurance payments were similar at baseline, the study cohort had a 33% payment reduction at one year compared with only a 10% reduction in the control group

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While the clinical significance remains uncertain, this raises the theoretical possibility of direct anti-inflammatory or chondroprotective effects

For background on how retatrutide works, see our mechanism of action guide