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If we dont change the oil filter periodically, the cars engine will diminish its performance and give less mileage. Similarly, if the balance between free radical production and antioxidant response in cells consistently favors the former, in time cellular function could be disrupted
It has been observed that intake of high content of phenolic compounds from olive oil (366 mg/kg) reduced the expression of CD40 ligand gene and its downstream products, and was associated with a decrease in oxidized LDL in plasma and an increase in urinary polyphenols (40)
In particular, this narrative review aims to explore how diverse upstream stimuli converge on common progression-related signaling circuits through ROS-mediated mechanisms
10.1016/j.tifs.2018.12.001 50 SuG.YangW.WangS.GengC.GuanX
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