They increase everyone to the maximum dose regardless of body size, sensitivity, or how much weight loss is actually needed
If the primary outcome showed superiority, secondary outcomes were tested in a pre-specified order to control the type I errors Total eGFR slope (the annual rate of change in eGFR from randomization to the end of the trial) Major cardiovascular events (a composite of nonfatal MI, nonfatal stroke, or death from CV causes) Death from any cause The other supportive secondary outcomes are shown in the figure below
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Consistent with this context, a concurrent analysis anchored at the time of maximum weight loss showed that greater achieved weight loss was not associated with lower cardiovascular risk over the next 24 months (Fig
Ozempic: Originally for diabetes but widely used off-label for obesity