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The conflicting data in some clinical studies may be explained by various factors: [1] most cohort studies lacked individual validation of fractures as primary outcomes, [2] the studies had short follow-up duration and [3] did not consider important risk factors for osteoporosis such as BMD (even though BMD is not a good method for diagnosing osteoporosis in T2DM), and [4] some studies included medications that affect fracture risk, such as corticosteroids or antidepressants
Healthier eating patterns, regular physical activity, and learning to manage appetite can reduce the risk of weight rebound often cited when patients stop or reduce the dose of medications
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Mild symptoms such as nausea or fatigue may occur at first
The compounded version aims to deliver the same active molecule through specialized compounding pharmacies rather than through Eli Lilly, the manufacturer of the brand-name products
