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others benefit from escalation to 2.4 mg or may require microdose protocols if standard doses trigger excessive side effects

Contraindications - Tirzepatide is contraindicated for patients with a personal or family history of Medullary Thyroid Cancer (MTC) or in patients with Multiple Endocrine Neoplasia syndrome type 2 - Risk of Thyroid C-Cell Tumors - Known serious hypersensitivity to tirzepatide or any of the excipients in it - Not recommended for patients with severe gastrointestinal disease - Patients with confirmed pancreatitis - Patients using Insulin Secretagogue (e.g

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The most frequently reported side effects include gastrointestinal symptoms such as nausea, vomiting, diarrhoea, and constipation, which typically diminish over time as the body adjusts to treatment

The main practical concern is overlapping GI side effects, since both can cause nausea, diarrhea, or stomach upset