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Traditionally, DKD is defined as a sequential evolution of stages characterized by a progressive increase in urinary albumin excretion (UAE) between 30 mg/day and 300 mg/day (formerly known as microalbuminuria) and followed by UAE levels greater than 300 mg/day or macroalbuminuria

Similar to what is observed in monocytes and macrophages, G6PD-d may limit the production of NADPH-dependent ROS that act as second messengers to enhance NFAT, AP-1, and NFB signaling 89,116,117

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