In parallel, redox-sensitive transcription factors such as NF-B are activated, upregulating adhesion molecules, chemokines, and pro-inflammatory cytokines (7)
How GLP-1 and Dual GIP/GLP-1 Agonists Work to Treat Obesity GLP-1 agonists and dual GIP/GLP-1 agonists are medications that increase satiety (the feeling of fullness), slow digestion, and quiet constant thoughts about food (known as food noise), making it easier to lose weight and keep it off
In experiments in mice and in samples of human skin, when the researchers used drugs to target these pathways, they were able to reactivate mature melanocytes and pigmentation-related genes and reverse many features of the dormant cells
A similar study published last year in Diabetes, Obesity and Metabolism found that switching from a weekly GLP-1 dose to a dose every other week helped people maintain about 75 percent of their weight loss

Current and resolved drug shortages and discontinuations reported to the FDA, Food and Drug Administration (2024) Regulatory framework for compounded preparations, National Academies Press (2020) Clinical and legal considerations in pharmaceutical compounding, The Journal of Clinical and Aesthetic Dermatology (2023) FDA alerts health care providers, compounders, and patients of dosing errors associated with compounded injectable semaglutide products, Food and Drug Administration (2024) Medications containing semaglutide marketed for Type 2 diabetes or weight loss, Food and Drug Administration (2024) FDA clarifies policies for compounders as national GLP-1 supply begins to stabilize, Food and Drug Administration (2025) Medically accurate: SingleCares Medical Review Board analyzes all of our content to confirm its in line with current medical advice