Mitochondrial Ca 2+ overload due to MCU overactivation increases Ca 2+ sensitivity, enhancing myosin light chain phosphorylation and promoting contraction, and mitochondrial ROS activate redox-sensitive pathways such as MAPK and NF-B, driving VSMC proliferation and neointima formation
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This novel tool, termed the Spearmans-Pearsons Decider, which expedited the processes needed to decide between a parametric or non-parametric analysis, is freely available at GitHub ( script and ReadMe in Supplementary Materials Scripts .zip file under Spearmans_Pearsons_Decider and ReadMe for Spearmans_Pearsons_Decider, respectively)
