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Their finding marked a decisive breakthrough because it challenged a long-standing belief that nerves controlled the secretion of digestive enzymes that had grown out of the work of Ivan Pavlov, the Russian physiologist who demonstrated that dogs can be conditioned to salivate by the sound of a bell (Rehfeld 2012)

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Review Your Dose With a Healthcare Professional If symptoms persist, your doctor might suggest slowing the rate of dose escalation or reducing the dose temporarily

Retatrutide remains investigational, with Phase 3 trials ongoing and potential approval not expected until mid-2026 or 2027 at the earliest

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