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Inhibition of translation initiation by antisense oligonucleotides via an RNase-H independent mechanism
This is unusual for peptides, which are typically degraded in the gastrointestinal tract
Polymeric nanoparticles in gene therapy: new avenues of design and optimization for delivery applications
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What stood out: CagriSema achieved 23.0% weight loss at 84 weeks (efficacy estimand) Tirzepatide achieved 25.5% On the treatment-regimen estimand, weight loss was 20.2% vs 23.6% Primary endpoint not met: CagriSema did not demonstrate non-inferiority vs tirzepatide on weight loss at 84 weeks Why this matters This is a reminder that in obesity pharmacotherapy, very effective and best-in-class are not the same conversation
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