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Obesity significantly increases loading forces on the knees, hips, ankles, and spine, accelerating cartilage degradation and contributing to osteoarthritis development and progression

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Orlistat also improved cardiovascular risk markers such as LDL, cholesterol, and blood pressure, and increased insulin sensitivity

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"Alcohol is already known to cause GI distress, such as upset stomach, diarrhea, and acid reflux, so you may feel even worse when its combined with the medication (which can also cause those things)," Weight Watchers noted