The AAFPs evidence-based clinical review states directly: Oral administration of high-dose vitamin B12 (1 to 2 mg daily) is as effective as intramuscular administration for correcting anemia and neurologic symptoms in patients with B12 deficiency (Langan RC, Goodbred AJ, American Family Physician, 2017)
All current evidence comes from preclinical animal and cellular studies, meaning its efficacy and safety in people remain unproven
Further, the periodic introduction of decreased maintenance doses during 2-3 months or for life is possible
If B12 is given without adequate folate, the methylation cycle can become inefficient
Each treatment performed at Reflections is tailored to the individual patient, to account for their needs, wants, and anatomy