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Creatine supplementation may modestly increase measured serum creatinine levels, which can confound creatinine-based estimated glomerular filtration rate (eGFR) calculations

Ethics and dissemination National Health and Research Council, Nepal (NHRC 253/2016) and Regional Committee for Medical and Health Research Ethics of Western Norway (2016/1620/REK vest) have approved the study

doi: 10.3389/fmicb.2019.01181 201 MassariP.HoY.WetzlerL

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The timeframe for observing results also plays a role short-term effects might call for a single, higher dose, while long-term studies may benefit from smaller, repeated doses