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The analogue, liraglutide, was effective in clinical studies (the LEAD trials [16]) and was subsequently tested in a cardiovascular outcome trial, the LEADER trial [17], as demanded by the FDA for new antidiabetic agents

(2020) Selection and progression of unimolecular agonists at the GIP, GLP-1, and glucagon receptors as drug candidates

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Use it as a baseline, then rotate foods you tolerate well

In this review, we aim to (1) provide a comprehensive overview of the structure and regulation of CYP51A1, (2) highlight its diverse roles in cellular homeostasis and death pathways, and (3) discuss its translational potential as a therapeutic target