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This is based on the observation that the livers of GCLM KO mice in all diet groups have high levels of active (phosphorylated) LKB1, a redox-sensitive kinase and the primary hepatic AMPK kinase 24

Side effects involve stomach issues like gas, loose stools, and discomfort from unused fat passing out of your body

While encouraging, this studys retrospective design, lack of placebo control, small sample size, and subjective outcome reporting limit its interpretability

DSIP, if effective, would layer on deeper slow-wave support rather than replace these staples

They target different cell populations and different aging mechanisms