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The most commonly reported side effects include: Nausea : Affecting 12% to 24% of patients with type 2 diabetes and 24% to 31% in weight management trials [1] [14] Diarrhea : 12% to 17% in diabetes trials and 18% to 23% in weight management trials Decreased appetite : 5% to 10% of patients Vomiting : 5% to 10% in diabetes trials and 8% to 12% in weight management trials Constipation : 5% to 7% in diabetes trials and 16% to 17% in weight management trials Dyspepsia : 5% to 9% of patients Abdominal pain : 5% to 9% of patients Alopecia (hair loss) : Reported in weight management trials These symptoms are typically mild to moderate in severity, occur most commonly during dose escalation, and tend to diminish over time as patients develop tolerance

And both produce gastrointestinal side effects that worsen with rapid titration or inappropriate dosing

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So there we can start thinking blood pressure and other things

When to Contact Your Provider About Semaglutide Fatigue Seek immediate medical advice if fatigue is accompanied by chest pain, severe shortness of breath, confusion, or fainting