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L-carnitine facilitates the mitochondrial eta-oxidation process and energy production by mediating the transport of long-chain fatty acids into the mitochondrial matrix (Ribas et al
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These changes in expression may be due to decreased glutathione and increased oxidative stress
An open-label, non-randomized trial in 69 patients with either type 1 or type 2 diabetes mellitus found a reduction in the incidence of muscle cramps and an improvement in the quality of life of those prescribed 0.6 g/day of L-carnitine for four months compared to controls (127)
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