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Long-term Considerations Some patients worry about semaglutide withdrawal symptoms diarrhea when considering long-term treatment
The Honest Answer Short answer: For healthy individuals using properly dosed, regulated oral glutathione there is no strong evidence showing it causes kidney damage
Morey L, Helin K
Measurement Methods Gold Standard: DEXA Scan Most accurate body composition measurement Shows exact muscle mass, bone density, fat mass Recommended every 3-4 months Cost: $50-150 per scan Accessible Options: Bioelectrical Impedance Scale: Less accurate but tracks trends ($30-100 one-time purchase) Progress Photos: Same lighting, same pose, same time of day, monthly Circumference Measurements: Waist, hips, thighs, arms, chest (use measuring tape) Strength Benchmarks: Track weights reps in your training log How Clothes Fit: Looser waist but same shoulder/thigh fit = good sign Red Flags That Suggest Muscle Loss Strength decreasing despite consistent training Losing more than 2-3 lbs per week consistently Feeling weaker or unusually fatigued during workouts Clothes fitting looser everywhere (not just waist) DEXA or BIA showing decreased lean mass If you notice these signs, increase protein intake by 20-30g daily and reassess in 2 weeks
Flow of patients through the trial Perkovic et al , NEJM 2024 The randomized participants had a mean age of 66.6 years
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