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Cancer cell biology research examining IGF1R-driven proliferation often uses LR3 as a standard reagent precisely because the dose-response across a multi-day proliferation assay is more interpretable when the ligand is stable in the media
Supplementary Figures Acknowledgements We would like to thank the Scientific Technology Platforms (STPs) at The Francis Crick Institute, particularly High Throughput Screening for their collaboration to develop the arrayed CRISPR-Cas9 screen, and the Biological Research Facility for breeding and maintenance of mouse lines
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Low vitamin D and elevated immunoreactivity against Epstein-Barr virus before first clinical manifestation of multiple sclerosis
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