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GSH-depleted HepG2 cells were treated with different concentrations of aspirin and membrane potential was measured using a cationic fluorescent dye as described in the Materials and Methods

It enables oxidation by dissolving oxygen that attacks vulnerable residues like methionine and cysteine

doi:10.1159/000117964 Schneider-Helmert D

Other studies reported lactic acidosis and increased alanine levels, it is highly recognized that high concentrations of lactate can inhibit mitochondrial respiration and disbalance the redox equilibrium (Oliveira et al., 2005)