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In vitro stability assay with high glutathione concentration GLP-1MK-801 was dissolved in dimethyl sulfoxide at a concentration of 0.25 mM and diluted with a solution of 200 mM glutathione in PBS, pH 7, such that the final concentration of GLP-1MK-801 in the assay was 100 M

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In this case, the levels of TMA in the blood and urine were measured before and after treatment, in addition to an next-generation sequencing (NGS) analysis of the intestinal microbiota