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2 3 4 5 6 7 Mounjaro (tirzepatide) KwikPen Summary of Product Characteristics, sections 4.4 and 4.8, MHRA/emc: The incidence of nausea, diarrhoea and vomiting occurred primarily during dose escalation and decreased over time. 2 Ozempic (semaglutide) 0.5 mg Summary of Product Characteristics, section 4.8, MHRA/emc: Nausea occurred in 17% and 19.9% of patients when treated with semaglutide 0.5 mg and 1 mg, respectively Most events were mild to moderate in severity and of short duration

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175 These findings support further use of PROM2-targeted intervention strategies in treating metastatic melanoma and other cancers