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Here is what the clinical evidence and typical patient experience looks like across the first year: Weeks 1 to 4 (2.5mg Mounjaro / 0.25mg Wegovy starter dose) Most women lose between 1 and 3kg in the first month

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This unique sex difference was subsequently confirmed in two follow-up studies, though with more modest reported improvements in female lifespan 7,8 , while a life shortening effect was observed in males 8

Think of it like a thermostat that was set at 72 degrees for months, then you turn it down

This modulatory effect appears to be adaptive