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instead, it has exposed how many endogenous peptide systems were evaluated prematurely, using tools and assumptions that no longer reflect the state of the field

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Some individuals report fewer intrusive food thoughts, reduced cravings for alcohol or other substances, and improved emotional regulation

Munson, George R

Beyond the toxic gain-of-function effects of mHTT, HD pathogenesis involves a range of interconnected mechanisms, including mitochondrial dysfunction, transcriptional dysregulation, impaired autophagy, proteostasis failure, excitotoxicity, oxidative stress, and chronic neuroinflammation [3843]