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The controls simultaneously received an equivolume of saline (5.0 ml/kg ip) or water only (12 ml/rat/day)

[1] [2] Common adverse effects include gastrointestinal symptoms such as nausea, vomiting, diarrhea, and constipation, which typically diminish with continued use

However, Lillys tirzepatide has some edges (e.g., trial efficacy and investor perception of pipeline strength) that have allowed Lilly to close the gap