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However, in an in vitro simulation of GI digestion, inulinase has been shown to effectively break down high-fructan ingredients, including inulin and garlic, as well as a high-fructan test meal containing garlic, onion, Brussels sprouts, and black beans.28 In addition, preliminary in-house randomized, blinded, placebo-controlled trials conducted by Kiwi Biosciences demonstrated significantly reduced flatulence and diarrhea events in healthy individuals who were given supplemental fructan hydrolase powder with a highly concentrated source of fructan in chicory root bars.26 More research is needed to determine whether inulinase and fructan hydrolase are effective tools for symptom management in IBS

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The expanding role of GLP-1 medications beyond weight loss, such as their potential to treat conditions like sleep apnea or chronic heart failure, represents an exciting shift in healthcare

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