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Firstly, NAC is safe even at high doses (exceeding 6 g/kg orally or 2 g/kg intravenously) (Bonanomi and Gazzaniga, 1980), while excessive cysteine intake can lead to severe pathological effects such as weight loss, cerebral damage, severe hypoglycemia, muscle spasms, and potentially fatal outcomes (EzEldeen et al., 2019)

This allows for a significant, sometimes dramatic shift in sleep quality

Furthermore, both cell development and the maintenance of different functions require the engagement of GPX4, as its genetic knockout or inactive form of expression leads to embryonic death lethality and subfertility in male mice (Ingold et al., 2015)

These findings underscore the complex bidirectional interactions between bone and brain, revealing potential therapeutic targets for cerebral ischemia and other neurological disorders (Figure 2)

Extrasynaptic NMDARs oppose synaptic NMDARs by triggering CREB shut-off and cell death pathways