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Prolonged Bleeding Time Indicates: Thrombocytopenia (low platelet count) Platelet function defects (e.g., Glanzmann thrombasthenia, BernardSoulier syndrome) Von Willebrand disease Vascular disorders Use of anti-platelet drugs (like aspirin, clopidogrel) Shortened or Normal Bleeding Time: Usually not clinically significant, but a normal result does not rule out all bleeding disorders

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Intracellular NAD metabolism is also spatially organized