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In contrast, patients with early-stage steatosis or those embedded in a context of profound systemic insulin resistance may present a less amenable target for short-term LC monotherapy, as the driving pathophysiology extends beyond immediate fatty acid flux

As this subgroup of ASD patients have several parallels with the rodent PPA model of ASD, 13 this rodent model may be a useful tool to further examine the temporal relation of behavioral bouts in relation to carnitine-acyl-carnitine fluctuations, and their possible response to therapeutic compounds thought to be useful in the treatment of ASD and mitochondrial dysfunction such as carnitine supplementation

10.3389/fendo.2024.1298628 Front Endocrinol

In the UKPDS cohort, the development of eGFR 300 mg/g) as the main renal outcome and the other trials addressing also eGFR-related endpoints, RRT and renal death (Table 1) [11]