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The second dominant phylum Bacteroidetes is mainly represented by the genera Bacteroides and Prevotella ( The microbial community provides numerous benefits for the host contributing to metabolism of nutrients, drugs, xenobiotics, maintenance of gut barrier function and intestinal immune homeostasis (Table 1 summarizes information regarding the experimental conditions and the identified microbiota-produced GRP metabolites

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Liver energy metabolism reprogramming: GLP-1RA reduces hepatic glucose output by decreasing hepatic FFA uptake and the expression of key gluconeogenesis enzymes such as PEPCK and G6Pase, while promoting liver sensitivity to insulin, transforming the liver from an "energy output organ" to an "energy storage organ"

Citation: Jastreboff, A

These findings and the underlying pathophysiological mechanisms suggest that GLP-1 analogs hold promise as a potential therapeutic approach for managing obesity and EDs [19]