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Research has documented MT-1s potent MC1R activation-driven melanogenesis in human and rodent melanocyte models , characterising dose-dependent cAMP elevation, MITF nuclear translocation, tyrosinase upregulation, melanin synthesis increases, and eumelanin versus phaeomelanin ratio shifts following MT-1 treatment

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PubMed Central , GLP-1 Agonists. Cleveland Clinic , 3 July 2023, Moiz, Areesha, et al

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