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10.1021/acsnano.4c12236 28 DaiS.YaoL.LiuL.CuiJ.SuZ.ZhaoA.et al (2024)
Gu S, Wang W, Ye G, Chen C, Zhou Y, Guo L, et al
Some participants in trials also reported fatigue, though this was not uniformly documented across all study arms
So while the raw numbers show headaches in trial participants, the signal was not strong enough relative to placebo to warrant special labeling
More studies should be conducted to fortify the blood-brain barrier and decrease cytokine-induced inflammation by targeting the oxidative cascade and preventing oxidative stress by enhancing mitochondrial function
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