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But the FDA's briefing documents flagged it as an uncharacterized risk requiring further investigation before any approval, and researchers continue to weigh the angiogenic mechanism against the compound's apparent safety profile in animal models

Timeline of effects by phase Weeks 1 through 4 (ultra-low doses, 0.125 to 0.5 mg): Most people feel nothing or very subtle appetite changes

Klicek R, et al

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