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The no-DAC version, often called modified GRF 1-29, is shorter acting

Upon stabilization of HIF- subunits under hypoxia, HIF-1 facilitates nuclear localization, DNA binding, and recruitment of transcriptional co-activators, thereby enabling the activation of hypoxia-responsive gene networks (5356)

J Clin Med Res

Assuming a medium concentration of 2.5 mM cytosolic GSH and an OxD GSH of 0.002% (Meyer et al., 2007) the Nernst equation predicts an E GSH of about 310 mV

Furthermore, their small size allows for easy synthesis and modification, facilitating their incorporation into drug-delivery systems or peptide-based therapeutics