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Due to the lack of commercially available reference compounds, the total concentrations of polyphenols and microbial metabolites are often measured after enzymatic cleavage of glucuronides and sulfates ( After intake of Pycnogenol , phase II conjugates of constituents and metabolites were present in plasma / serum samples (Table 3), followed by caffeic acid with 80%

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Thus, selenium supplementation should be carefully monitored in terms of the plasma selenium concentration to obtain the desired health benefits without any toxicological side effects