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The intermediate ACMS can cyclize spontaneously to QA

where F = phenylalanine, L = leucine, and X = any amino acid residue a Polyglutamine repeat [59] (AR-B only) Transactivation unit 1 (TAU-1) between residues 101 and 370 required for full ligand-activated transcriptional activity [60] Transactivation unit 5 (TAU-5) between residues 360485 is responsible for the constitutive activity (activity without bound ligand) [60] Despite being highly disordered, the NTD domain adopts a 3D conformation in which two dynamically compact regions form, an N-terminal region (NR) and a C-terminal region (CR), each having distinct topological dynamics and function

Patterns aggregated from public GLP-1 user reports (paraphrased

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