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IV use at appropriate infusion rates has not shown the same risk profile, but medical history review is standard Individuals with a known sensitivity to sulfur-containing compounds should inform their provider High-dose IV glutathione for cosmetic skin lightening, particularly in unregulated settings, has been associated with adverse events including anaphylaxis and reports of hepatotoxicity

The absorbance was measured at 412 nm and GSH content expressed as mol/gHb (13)

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107 , e3497e3503 (2022)

Further large-scale studies with longer follow-up periods are recommended to validate these findings